Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy

Fleitas, Tania; Martinez Ciarpaglini, Carolina; Ayala, Josefina; Gauna, Cinthia; Denis, Rita Mabel Concepción; Yoffe, Ita; Sforza, Silvia; Martínez de Filártiga Filártiga, María Teresa; Pomata, Alicia; Ibarrola‐Villava, Maider; Arevshatyan, Sipan; Burriel, Verónica; Boscá, Diego; Pastor, Oscar; Ferrer, Ana; Carrasco, Francisca; Mongort, Cristina; Navarro, Samuel; Ribas, Gloria; Cervantes, Andres

doi:10.1002/cam4.2191

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http://hdl.handle.net/20.500.14066/3656

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Fecha de publicación

2019

Tipo de publicación

research article

Materia(s)

COLORECTAL CANCER
MICROSATELLITE INSTABILITY
MUTATIONAL PROFILE
ONCOCARTA
PRECISION MEDICINE

Resumen

Somatic mutation analysis and evaluation of microsatellite instability (MSI) have become mandatory for selecting personalized therapy strategies for advanced colorectal cancer and are not available as routine methods in Paraguay. The aims of this study were to analyze the molecular profile as well as the microsatellite status in a series of advanced colorectal patients from two public hospitals from Paraguay, to introduce these methodologies in the routine practice to guide the therapeutic decisions.

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