RT Journal Article
T1 Anticuerpo anti-transglutaminasa tisular en adultos con enfermedad celíaca y su relación con la presencia y duración de la dieta libre de gluten
T2 Anti-transglutaminase antibody in adults with celiac disease and their relation to the presence and duration of gluten-free diet
A1 Ferreira Maniero, Silvia Cristina
A1 Chamorro, María Elena
A1 Ortíz, Jesús
A1 Carpinelli, María Mercedes
A1 Giménez Bareiro, Vivian
A1 Langjahr Penayo, Patricia Elena
A2 Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud
AB Introduction: IgA anti-transglutaminase 2 (tTG2) antibody is a relevant marker in celiac disease. The utility of IgA anti-tTG2 determination is well established for the diagnosis, however their use in the follow-up of patients with gluten free diet (GFD) it is not fully established.Objective: To determine IgA anti-tTG2 antibody levels in adult Paraguayan celiac disease patients and its relation to the presence and duration of the GFD.Materials and methods: Adult celiac disease patients without (n=23) or with (n=49) GFD were included in this observational, descriptive, cross-sectional study with analytical component. IgA anti-tTG2 antibody serum levels were analyzed by ELISA. Results: All (100%) celiac disease patients without GFD had  positive anti-tTG2 IgA. Serum levels of IgA anti-tTG2 were significantly elevated in celiac disease patients without GFD compared to levels in patients with GFD. 35% of patients treated with GFD (diet average duration = 5.7 years) had positive (29%) or indeterminate (6%) levels of IgA anti-tTG2. In terms of GFD duration we observed that while the GFD period increased, antibody levels decreased (r=-0.2963; p=0.0387).Conclusion: IgA anti-tTG2 antibody levels correlated inversely with the GFD duration. However, positive levels of these antibodies persisted in some patients, even several years after the onset of GFD.
PB Sociedad de Gastroenterología del Perú
SN 1022-5129
YR 2018
FD 2018-12-06
LK http://hdl.handle.net/20.500.14066/2957
UL http://hdl.handle.net/20.500.14066/2957
LA spa
NO Ferreira, S., Chamorro, M. E., Ortíz, J., Carpinelli, M. M., Giménez, V., & Langjahr, P. (2018). Anticuerpo anti-transglutaminasa tisular en adultos con enfermedad celíaca y su relación con la presencia y duración de la dieta libre de gluten. Revista de Gastroenterología del Perú, 38(3), 228–33. https://doi.org/10.47892/rgp.2018.383.905
NO Correspondencia: Patricia Elena Langjahr Penayo. Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción. Campus Universitario, Dr. Cecilio Báez c/ Dr. Gaspar Villamayor, San Lorenzo, Paraguay. Código postal 2169. E-mail: plangjahr@gmail.com
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 25-abr-2025