RT Journal Article T1 Combining Interactomes from Multiple Organisms: a Case Study on Human-Mouse A1 Cáceres Silva, Juan José A1 Paccanaro, Alberto A2 University of London (UK) AB The amount and quality of available data on different organisms varies greatly. While model organisms benefit from extensive experimental studies, there is often a lack of detailed experimental data for more specific organisms. Additionally, even among model organisms there are noticeable differences in the amount and type of data available, due to the different suitability of experiments in different organisms.The combination of interactomes for closely related species, represents a viable tool to increase the amount of protein- proteininteraction data for a given organism. The Human-Mouse case of study is particularly relevant, as many experiments cannot becarried out on humans. This paper describes a general method to construct a combined interactome from different organisms. YR 2016 FD 2016 LK http://hdl.handle.net/20.500.14066/2997 UL http://hdl.handle.net/20.500.14066/2997 LA eng NO CONACYT – Consejo Nacional de Ciencia y Tecnología DS MINDS@UW RD 23-nov-2024