RT info:eu-repo/semantics/article T1 A mathematical model for COVID-19 with variable transmissibility and hospitalizations : a case study in Paraguay A1 Shin, Hyun Ho A1 Sauer Ayala, Carlos Eugenio A1 Pérez Estigarribia, Pastor Enmanuel A1 Grillo, Sebastián Alberto A1 Segovia Cabrera, Leticia María Alejandra A1 García Torres, Miguel A1 Gaona Ruiz Díaz, Carlos Federico A1 Irala Cabrera, Sandra Verónica A1 Pedrozo, Maria Esther A1 Sequera Buzarquis, Víctor Guillermo A1 Vázquez Noguera, José Luis A1 De los Santos Núñez, Eduardo Antonio A2 Universidad Autónoma de Asunción AB Forecasting the dynamics of the number of cases with coronavirus disease 2019 (COVID-19) in a given population is a challenging task due to behavioural changes which occur over short periods. Planning of hospital resources and containment measures in the near term require a scenario analysis and the use of predictive models to gain insight into possible outcomes for each scenario. In this paper, we present the SEIR-H epidemiological model for the spread dynamics in a given population and the impact of COVID-19 in the local health system. It was developed as an extension of the classic SEIR model to account for required hospital resources and behavioural changes of the population in response to containment measures. Time-varying parameters such as transmissibility are estimated using Bayesian methods, based on the database of reported cases with a moving time window strategy. The assessment of the model offers reasonable results with estimated parameters and simulations, reflecting the observed dynamics in Paraguay. The proposed model can be used to simulate future scenarios and possible effects of containment strategies, to guide the public institution response based on the available resources in the local health system. PB Multidisciplinary Digital Publishing Institute YR 2021 FD 2021-10-18 LK http://hdl.handle.net/20.500.14066/3801 UL http://hdl.handle.net/20.500.14066/3801 LA eng NO Shin, H. H., Sauer Ayala, C., Pérez Estigarribia, P., Grillo, S., Segovia Cabrera, L., García Torres, M., Gaona, C., Irala, S., Pedrozo, M. E., Sequera, G., Vázquez Noguera, J. L., & De Los Santos, E. (2021). A mathematical model for COVID-19 with variable transmissibility and hospitalizations: a case study in Paraguay. Applied Sciences, 11(20), Artículo 9726.https://doi.org/ 10.3390/app11209726 NO Correspondence: csauer@uaa.edu.py; Tel.: +595-9-8436-8483 NO Consejo Nacional de Ciencia y Tecnología DS MINDS@UW RD 21-nov-2024