RT Journal Article T1 Two-dimensional gel electrophoresis to study the activity of type iia topoisomerases on plasmid replication intermediates A1 Cebrian, Jorge A1 Martínez, Víctor A1 Hernández, Pablo A1 Krimer, Dora A1 Fernández Nestosa, María José A1 Schvartzman, Jorge Bernardo A2 Universidad Nacional de Asunción - Facultad Politécnica AB DNA topoisomerases are the enzymes that regulate DNA topology in all living cells. Since the discovery and purification of ω (omega), when the first were topoisomerase identified, the function of many topoisomerases has been examined. However, their ability to relax supercoiling and unlink the pre-catenanes of partially replicated molecules has received little attention. YR 2021 FD 2021-11 LK http://hdl.handle.net/20.500.14066/3839 UL http://hdl.handle.net/20.500.14066/3839 LA eng NO CONACYT – Consejo Nacional de Ciencia y Tecnología DS MINDS@UW RD 29-mar-2024