RT Journal Article T1 CRISPR/Cas9-mediated deletion of the Wiskott-Aldrich syndrome locus causes actin cytoskeleton disorganization in murine erythroleukemia cells A1 Fernández-Calleja, Vanessa A1 Fernández Nestosa, María José A1 Hernández, Pablo A1 Schvartzman, Jorge Bernardo A1 Krimer, Dora A2 Universidad Nacional de Asunción - Facultad Politécnica AB Wiskott-Aldrich syndrome (WAS) is a recessive X-linked inmmunodeficiency caused by loss-of-function mutations in the gene encoding the WAS protein (WASp). WASp plays an important role in the polymerization of the actin cytoskeleton in hematopoietic cells through activation of the Arp2/3 complex. In a previous study, we found that actin cytoskeleton proteins, including WASp, were silenced in murine erythroleukemia cells defective in differentiation. YR 2019 FD 2019-01 LK http://hdl.handle.net/20.500.14066/3848 UL http://hdl.handle.net/20.500.14066/3848 LA eng NO CONACYT – Consejo Nacional de Ciencia y Tecnología DS MINDS@UW RD 06-oct-2024