RT Journal Article T1 Distribution of torsional stress between the un- replicated and replicated regions in partially replicated molecules A1 Martínez, Víctor A1 Schaerer Serra, Christian Emilio A1 Hernández, Pablo A1 Krimer, Dora A1 Schvartzman, Jorge Bernardo A1 Fernández Nestosa, María José A2 Universidad Nacional de Asunción - Facultad Politécnica AB DNA topology changes continuously as replication proceeds. Unwinding of the DNA duplex by helicases is favored by negative supercoiling but it causes the progressive accumulation of positive supercoiling ahead of the fork. This torsional stress must be removed for the fork to keep advancing.Elimination of this positive torsional stress may be accomplished by topoisomerases acting solely ahead of the fork or simultaneously in the un-replicated and replicated regions after diffusion of some positive torsional strain from the un-replicated to the replicated regions by swivelling of the replication forks. SN 0739-1102 (Print) 1538-0254 (Online) YR 2020 FD 2020-04 LK http://hdl.handle.net/20.500.14066/3851 UL http://hdl.handle.net/20.500.14066/3851 LA eng NO CONACYT – Consejo Nacional de Ciencia y Tecnología DS MINDS@UW RD 28-mar-2024