RT info:eu-repo/semantics/article
T1 In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract
A1 Taboada, Teresa
A1 Alvarenga Sosa, Nelson Luis
A1 Galeano, Antonia K.
A1 Arrúa, Wilfrido J.
A1 Campuzano Bublitz, Miguel A.
A1 Kennedy, María L.
A2 Universidad Nacional de Asunción. Facultad de Ciencias Químicas
AB Medicinal plants belonging to the Verbenaceae family demonstrated antidepressant effects in preclinical studies. Depression is one of the largest contributors to the global health burden of all countries. Plants from the Aloysia genus are traditionally used for affective disorders, and some of them have proven anxiolytic and antidepressant activity. The aim of this work was to evaluate the antidepressant effect of the ethanolic extract of Aloysia gratissima var. gratissima (Agg) and Aloysia virgata var. platyphylla (Avp) in mice. A tail suspension test (TST) and forced swimming test (FST) were conducted after three doses in a period of 24 h and after 7 days of treatment. Imipramine was used as an antidepressant drug. The main results demonstrated that Agg extract reduced the immobility time in mice treated orally for 7 consecutive days when compared to the control group (reduced by about 77%, imipramine 70%). Animals treated with three doses of Avp in a 24-h period had reduced immobility time in the FST (60%), and after 7 days of treatment the reduction was greater (Avp 50, 100, and 200 about 85%; Avp 400, 96.5%; p < 0.0001, imipramine, 77%). LCMS analysis showed the presence of verbascoside, hoffmaniaketone, and hoffmaniaketone acetate in both, A. virgata var. platyphylla and A. gratissima var gratissima. The flavonoids nepetin and 6-hydroxyluteolin were also found in Agg. Both tested extracts demonstrated promising antidepressant-like activity in mice.
PB Multidisciplinary Digital Publishing Institute
YR 2022
FD 2022-11-13
LK http://hdl.handle.net/20.500.14066/4376
UL http://hdl.handle.net/20.500.14066/4376
LA eng
NO Taboada, T.; Alvarenga, N.L.; Galeano, A.K.; Arrúa,W.J.; Campuzano Bublitz, M.A.; Kennedy, M.L. In vivo antidepressant-like effect assessment of two Aloysia species in mice and LCMS chemical characterization of ethanol extract. Molecules 2022, 27, 7828. https://doi.org/10.3390/molecules27227828
NO Correspondence: lukenrol@qui.una.py or mkennedy.rolon@gmail.com
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 05-jul-2024