RT info:eu-repo/semantics/review
T1 Amazonian scorpions and scorpionism : integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world’s most diverse rainforest
A1 Borges Strauss, Adolfo
A1 Graham, Matthew R.
A1 Cândido, Denise M.
A1 Pardal, Pedro P. O.
A2 Centro para el Desarrollo de la Investigación Científica
AB Venom from Amazonian scorpions of the genus Tityus contains components capable of eliciting a distinct clinical, mostly neurological, syndrome. This contrasts with the mainly autonomic manifestations produced after envenomation by congeneric southern and northern South American species. Herein, we summarize Pan-Amazonian scorpionism by synthesizing available toxinological, clinical, and molecular data gathered from all affected areas in Amazonia, including Brazil, Ecuador, Colombia, Peru, Venezuela, and French Guiana. We searched multiple databases, as well as our own records, for reports of scorpion envenomations in Amazonia by confirmed Tityus spp., and compared the clinical manifestations. To help uncover clinical and venom relationships among problematic species, we explored phylogenetic relationships with a rate-calibrated analysis of mitochondrial COI data from available species. The possible existence of diversity gradients for venom toxic and immunogenic components despite the predicted strong phylogenetic association among species is underscored by discussed clinical and toxinological findings. A multicentric effort, involving all nations affected by this neglected disease, is urgently needed to offer alternatives for treating and understanding this pathology, including the preparation of neutralizing antibodies with a broad range of efficacy.
PB São Paulo State University. Center for the Study of Venoms and Venomous Animals
YR 2021
FD 2021-11-29
LK http://hdl.handle.net/20.500.14066/4393
UL http://hdl.handle.net/20.500.14066/4393
LA eng
NO Borges, A., Graham, M. R., Cândido, D. M., & Pardal, P. P. O. (2021). Amazonian scorpions and scorpionism: integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world's most diverse rainfores. Journal of Venomous Animals and Toxins including Tropical Diseases, 27, e20210028. https://doi.org/10.1590/1678-9199-JVATITD-2021-0028
NO Correspondence: borges.adolfo@gmail.com
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 14-may-2024