RT info:eu-repo/semantics/article
T1 Multicentric study of cervical cancer screening with human papillomavirus testing and assessment of triage methods in Latin America : the ESTAMPA screening study protocol
A1 Almonte, Maribel
A1 Murillo, Raúl
A1 Sánchez, Gloria Inés
A1 González, Paula
A1 Ferrera, Annabelle
A1 Picconi, María Alejandra
A1 Wiesner, Carolina
A1 Cruz Valdez, Aurelio
A1 Lazcano Ponce, Eduardo
A1 Jerónimo, José
A1 Ferreccio, Catterina
A1 Kasamatsu, Elena Satiko
A1 Mendoza Torres, Laura Patricia
A1 Rodríguez, Guillermo
A1 Calderón, Alejandro
A1 Venegas, Gino
A1 Villagra, Veronica
A1 Tatti, Silvio
A1 Fleider, Laura
A1 Terán, Carolina
A1 Baena, Armando
A1 Hernández, María de la Luz
A1 Rol, Mary Luz
A1 Lucas, Eric
A1 Barbier, Sylvaine
A1 Ramírez, Arianis Tatiana
A1 Arrossi, Silvina
A1 Rodríguez Riveros, María Isabel
A1 González, Emmanuel
A1 Celis, Marcela
A1 Martínez, Sandra
A1 Salgado, Yuly
A1 Ortega, Marina
A1 Beracochea, Andrea Verónica
A1 Pérez, Natalia
A1 Rodríguez de la Peña, Margarita
A1 Ramón, María
A1 Hernández Nevarez, Pilar
A1 Arboleda Naranjo, Margarita
A1 Cabrera, Yessy
A1 Salgado, Brenda
A1 García, Laura
A1 Retana, Marco Antonio
A1 Colucci, María Celeste
A1 Arias Stella, Javier
A1 Bellido Fuentes, Yenny
A1 Bobadilla Frizzola, María Liz
A1 Olmedo, Gladys
A1 Brito García, Ivone
A1 Méndez Herrera, Armando
A1 Cardinal, Lucía
A1 Flores, Betsy
A1 Peñaranda, Jhacquelin
A1 Martínez Better, Josefina
A1 Soilan, Ana María
A1 Figueroa, Jacqueline
A1 Caserta, Benedicta
A1 Sosa, Carlos
A1 Moreno, Adrián
A1 Mural, Juan
A1 Doimi, Franco
A1 Giménez, Diana
A1 Rodríguez, Hernando
A1 Lora, Oscar
A1 Luciani, Silvana
A1 Broutet, Nathalie
A1 Darragh, Teresa M.
A1 Herrero, Rolando
AB Introduction. Human papillomavirus (HPV) testing is replacing cytology in primary screening. Its limited specificity demands using a second (triage) test to better identify women at high-risk of cervical disease. Cytology represents the immediate triage but its low sensitivity might hamper HPV testing sensitivity, particularly in low-income and middle-income countries (LMICs), where cytology performance has been suboptimal. The ESTAMPA (EStudio multicéntrico de TAMizaje y triaje de cáncer de cuello uterino con pruebas del virus del PApiloma humano; Spanish acronym) study will: (1) evaluate the performance of different triage techniques to detect cervical precancer and (2) inform on how to implement HPV-based screening programmes in LMIC.Methods and analysis. Women aged 30–64 years are screened with HPV testing and Pap across 12 study centres in Latin America. Screened positives have colposcopy with biopsy and treatment of lesions. Women with no evident disease are recalled 18 months later for another HPV test; those HPV-positive undergo colposcopy with biopsy and treatment as needed. Biological specimens are collected in different visits for triage testing, which is not used for clinical management. The study outcome is histological high-grade squamous intraepithelial or worse lesions (HSIL+) under the lower anogenital squamous terminology. About 50 000 women will be screened and 500 HSIL+ cases detected (at initial and 18 months screening). Performance measures (sensitivity, specificity and predictive values) of triage techniques to detect HSIL+ will be estimated and compared with adjustment by age and study centre.Ethics and dissemination. The study protocol has been approved by the Ethics Committee of the International Agency for Research on Cancer (IARC), of the Pan American Health Organisation (PAHO) and by those in each participating centre. A Data and Safety Monitoring Board (DSMB) has been established to monitor progress of the study, assure participant safety, advice on scientific conduct and analysis and suggest protocol improvements. Study findings will be published in peer-reviewed journals and presented at scientific meetings.
PB BMJ Publishing Group
YR 2020
FD 2020-05-24
LK http://hdl.handle.net/20.500.14066/4422
UL http://hdl.handle.net/20.500.14066/4422
LA eng
NO Almonte, M., Murillo, R., Sánchez, G. I., González, P., Ferrera, A., Picconi, M. A., Wiesner, C., Cruz-Valdez, A., Lazcano-Ponce, E., Jerónimo, J., Ferreccio, C., Kasamatsu, E., Mendoza, L., Rodríguez, G., Calderón, A., Venegas, G., Villagra, V., Tatti, S., Fleider, L., Terán, C., … Herrero, R. (2020). Multicentric study of cervical cancer screening with human papillomavirus testing and assessment of triage methods in Latin America: the ESTAMPA screening study protocol. BMJ open, 10(5), e035796. https://doi.org/10.1136/bmjopen-2019-035796
NO Correspondence to Dr Maribel Almonte; almontem@iarc.fr
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 10-jul-2024