RT info:eu-repo/semantics/article
T1 Association between vitamin D deficiency and disease activity in Paraguayan patients with systemic lupus erythematosus
T2 Asociación entre la deficiencia de vitamina D y la actividad de la enfermedad en pacientes paraguayos con lupus eritematoso sistémico
A1 Acosta Colmán (de Conrads), María Isabel
A1 Morel, Zoilo Ramón Pastor
A1 Paats, Astrid
A1 Ortíz, Nelson
A1 Román, Lourdes
A1 Vázquez, Marcos
A1 Duarte, María Margarita
A1 Avila Pedretti, Gabriela
A1 Acosta de Hetter, María Eugenia
A1 Martínez de Filártiga Filártiga, María Teresa
A2 Laboratorio Curie S.R.L
AB Objective. To identify the association between vitamin D (VD) concentrations and the activity of systemic lupus erythematosus (SLE) and determine a supplementation dose that allows patients to maintain adequate levels of VD.Methods. Longitudinal, observational study. Serum levels of 25-hydroxy-VD were measured in 100 Paraguayan SLE patients from the Hospital de Clínicas between 2016 and 2018. To analyze the response to different doses of VD supplementation, 50 patients received 1000 IU/day and the other 50 patients received 2000 IU. SLE disease activity measured by SELENA-SLEDAIwas scored before and after supplementation.Results. The mean age was 27.5 ± 9.8 years, 88.9% of patients presented mild disease activity and 11.1% presented moderate to severe activity. The mean VD concentration was 30.8 ± 11.8 ng/mL. A total of 34% of patients presented VD insufficiency and 13% VD deficiency. There was an inverse relationship between VD concentrations and SLE disease activity (p = 0.03). Increasing levels of serum VD are associated with supplementation of 2000 IU/day (p = 0.0224).Conclusion. SLE activity was associated with low levels of VD. In our cohort, SLE patients required a supplementation dose equal to or greater than 2000 IU/day to increase their serum VD.
PB Asociación Colombiana de Reumatología
SN 0121-8123
YR 2021
FD 2021-08-28
LK http://hdl.handle.net/20.500.14066/4456
UL http://hdl.handle.net/20.500.14066/4456
LA eng
NO Corresponding author. dr.acostacolman@gmail.com
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 08-sep-2024