RT info:eu-repo/semantics/article
T1 Antioxidant activity, antiproliferative activity, antiviral activity, no production inhibition, and chemical composition of essential oils and crude extracts of leaves, flower buds, and stems of Tetradenia riparia
A1 da Silva Sena, Jéssica
A1 Alves Rodrigues, Selma
A1 Sakumoto, Karina
A1 Sadao Inumaro, Rodrigo
A1 González Maldonado, Pamela
A1 Mendez Scolari, Emilio
A1 Piau, Ranulfo Jr.
A1 Dib Gonçalves, Daniela
A1 Mandim, Filipa
A1 Vaz, Josiana
A1 Gonçalves, José Eduardo
A1 Sotelo Torres, Pablo Hernán
A1 Silveira do Valle, Juliana
A1 Cristiani Gazim, Zilda
A2 Fundación Facultad de Ciencias Químicas
AB The chemical composition of extracts (CEs) and essential oils (EOs) from Tetradenia riparia leaves, flower buds, and stems was analyzed. Antiproliferative activity against tumor cell lines, NO production inhibition, and antioxidant and antiviral activities were assessed. The CEs contained flavonoids, phenolic acids, coumarins, and saturated fatty acids. The EOs included monoterpenes, oxygenated sesquiterpenes, and diterpenes. NO production inhibition ranged from 76 to 247 µg mL−1, and antiproliferative activity exhibited GI50 between 20 and >204 µg mL−1, with low cytotoxicity (SI: 1.08 to 4.75). Reactive oxygen species inhibition ranged from 45 to 82%. Antioxidant activity varied when determined by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay (IC50: 0.51 to 8.47 mg mL−1) and ferric reducing antioxidant power (0.35 to 0.81 µM ferrous sulfate per mg). The reduction in β-carotene–linoleic acid co-oxidation varied between 76.13 and 102.25%. The total phenolic content of CEs and EOs was 10.70 to 111.68 µg gallic acid mg−1. Antiviral activity against herpes simplex virus type 1 (HSV-1) showed an EC50 between 9.64 and 24.55 µg mL−1 and an SI between 8.67 and 15.04. Leaf EOs exhibited an EC50 of 9.64 µg mL−1 and an SI of 15.04. Our study unveils the diverse chemical composition and multifaceted pharmacological properties of T. riparia, demonstrating its potential as a valuable source of bioactive compounds for therapeutic applications.
PB Multidisciplinary Digital Publishing Institute
YR 2024
FD 2024-07-04
LK http://hdl.handle.net/20.500.14066/4498
UL http://hdl.handle.net/20.500.14066/4498
LA eng
NO Da Silva Sena, J., Alves Rodrigues, S., Sakumoto, K., Sadao Inumaro, R., González Maldonado, P., Mendez Scolari, E., Piau, Jr., R., Dib Gonçalves, D., Mandim, F., Vaz, J., Gonçalves, J. E., Sotelo, P. H., Silveira do Valle, J., & Cristiani Gazim, Z. (2024). Antioxidant activity, antiproliferative activity, antiviral activity, no production inhibition, and chemical composition of essential oils and crude extracts of leaves, flower buds, and stems of Tetradenia riparia. Pharmaceuticals, 17(7), Artículo 888. https://doi.org/10.3390/ph17070888
NO Correspondence: Zilda Cristiani Gazim, cristianigazim@prof.unipar.br
NO This article belongs to the Special Issue Anticancer Compounds in Medicinal Plants - In Honour of the 20th Anniversary of Pharmaceuticals.
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 22-ene-2025