RT info:eu-repo/semantics/article
T1 Acrocomia aculeata (Mbokaja) kernel oil inhibits herpes simplex virus 1 replication and promotes cutaneous wound healing in infected mice
A1 Villalba Aucejo, Ana Belén
A1 Correa Quevedo, María Laura
A1 Cáceres Villalba, María Paz
A1 Romero Saldivar, Gladys Azucena
A1 Galeano Ruiz Díaz, Antonia Karina
A1 Rivaldi Chávez, Juan Daniel
A1 Langjahr Penayo, Patricia Elena
A1 Sotelo Torres, Pablo Hernán
AB Background/Objectives: Herpes simplex virus type 1 (HSV-1) is a global and prevalent pathogen, presenting significant clinical challenges because of its recurring infections, the development of drug resistance and severe clinical complications. This study evaluated the antiviral efficacy against HSV-1 of Acrocomia aculeata (A. aculeata) kernel oil, a Neotropical palm native to the Americas. Methods: The chemical profile of A. aculeata kernel oil was determined by gas chromatography with flame ionization detection (GC-FID). Antiviral activity was assessed using dose–response curves, time-of-addition assays, and quantification of intracellular viral genomes, viral gene transcripts, and IL-6 expression. A. aculeata kernel oil’s antiviral effect was also evaluated using an in vivo HSV-1 cutaneous infection model. Results: GC-FID analysis revealed lauric, oleic, and myristic acids as predominant components in the kernel oil. A. aculeata kernel oil exhibited potent antiviral activity against HSV-1. The oil inhibited HSV-1 early step post-entry, reducing the mRNA levels of the immediate-early genes ICP4 and ICP22, leading to the downregulation of early and late viral gene expression and intracellular viral genome. Furthermore, the oil suppressed IL-6 expression in infected cells. Importantly, A. aculeata kernel oil promoted the healing of cutaneous lesions in HSV-1-infected mice. Conclusions: These findings demonstrate that A. aculeata kernel oil is a promising candidate for developing novel antiviral and topical therapies against HSV-1.
PB Multidisciplinary Digital Publishing Institute
YR 2026
FD 2026-09-03
LK http://hdl.handle.net/20.500.14066/4851
UL http://hdl.handle.net/20.500.14066/4851
LA eng
NO Villalba Aucejo, A. B., Correa Quevedo, M. L., Cáceres-Villalba, M. P., Saldivar, G. A. R., Galeano, A., Rivaldi Chavez, J. D., Langjahr, P., & Sotelo, P. H. (2026). Acrocomia aculeata (Mbokaja) Kernel Oil Inhibits Herpes Simplex Virus 1 Replication and Promotes Cutaneous Wound Healing in Infected Mice. Molecules, 31(17), 3092. https://doi.org/10.3390/molecules31173092
NO Correspondence: phsotelo@qui.una.py.
NO This article belongs to the Special Issue Natural Products Chemistry in the Americas.
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 08-oct-2026