RT Journal Article
T1 CRISPR/Cas9-mediated deletion of the Wiskott-Aldrich syndrome locus causes actin cytoskeleton disorganization in murine erythroleukemia cells
A1 Fernández-Calleja, Vanessa
A1 Fernández Nestosa, María José
A1 Hernández, Pablo
A1 Schvartzman, Jorge Bernardo
A1 Krimer, Dora
A2 Universidad Nacional de Asunción - Facultad Politécnica
AB Wiskott-Aldrich syndrome (WAS) is a recessive X-linked inmmunodeficiency caused by loss-of-function mutations in the gene encoding the WAS protein (WASp). WASp plays an important role in the polymerization of the actin cytoskeleton in hematopoietic cells through activation of the Arp2/3 complex. In a previous study, we found that actin cytoskeleton proteins, including WASp, were silenced in murine erythroleukemia cells defective in differentiation.
YR 2019
FD 2019-01
LK http://hdl.handle.net/20.500.14066/3848
UL http://hdl.handle.net/20.500.14066/3848
LA eng
NO CONACYT – Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 20-dic-2024