RT Journal Article
T1 Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients
A1 Acosta Colmán (de Conrads), María Isabel
A1 Morel, Zoilo Ramón Pastor
A1 Ayala Lugo, Ana Ilda
A1 Jolly, Valerie
A1 Arévalo de Guillén, Ivalena
A1 Langjahr Penayo, Patricia Elena
A1 Vázquez, Marcos
A1 Martínez de Filártiga, María Teresa
A1 Acosta de Hetter, María Eugenia
A2 Laboratorio Curie S.R.L
AB Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a heterogeneous clinical picture that makes the diagnosis and follow-up of these patients difficult. This study aimed to identify correlations between clinical, immunological, and genetic biomarkers and clinical manifestations in SLE. A retrospective study of data from medical records and immunological and genetic studies of SLE patients in Paraguay was carried out. A descriptive analysis was performed based on the type of variable. Human leukocyte antigen (HLA) allele frequencies (DPA1, DPB1, DQA1, DQB1, and DRB1) were calculated, and univariate logistic regression analyses were performed between each of the explanatory variables and the presence or absence of each phenotype. Odds ratios, 95% confidence intervals, and p values were recorded. Associations with p<0.05 were considered statistically significant. 104 SLE patients were included: 86% were female, with a mean age of 32.80±10.36 years. An association was identified between anti-double stranded DNA (antidsDNA) and the presence of the renal phenotype and between anti-dsDNA and the absence of the joint and hematological phenotypes. Immunoglobulin M isotype rheumatoid factor was associated with the absence of a renal phenotype. HLA-DQB1*02:02 and HLA-DRB1*07:01 were associated with the cutaneous phenotype. An association was identified between age at disease onset over 30 years and the presence of the joint phenotype. No other associations were identified. Potential clinical, immunological, and genetic biomarkers of phenotypes have been identified in SLE Paraguayan patients.
PB PAGEPress
SN 2240-2683
YR 2023
FD 2023-07-17
LK http://hdl.handle.net/20.500.14066/4307
UL http://hdl.handle.net/20.500.14066/4307
LA eng
NO Acosta-Colman, I., Morel, Z., Ayala Lugo, A., Jolly, V., de Guillén, I., Langjahr, P., Vázquez, M., Martínez de Filártiga, M., & Acosta, M. (2023). Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients. Reumatismo, 75 (2). https://doi.org/10.4081/reumatismo.2023.1541
NO Corresponding author: Isabel Acosta-Colman, Department of Rheumatology, Faculty of Medical Sciences, National University of Asunción, San Lorenzo, Paraguay; email: dr.acostacolman@gmail.com
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 04-nov-2024