RT info:eu-repo/semantics/article
T1 Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population
A1 Samudio, Angélica
A1 Sotelo Torres, Pablo Hernán
A1 González Maldonado, Pamela
A1 Alfonso, Laura
A1 Valiente Echeverría, Fernando
A1 Soto Rifo, Ricardo
A1 Langjahr Penayo, Patricia Elena
A2 Fundación Facultad de Ciencias Químicas
A2 Fundación Centro de Información y Recursos para el Desarrollo
AB Introduction: Severe Acute Respiratory Syndrome-Coronavirus-2 Virus (SARS-CoV-2) is responsible for Coronavirus Disease 2019 (COVID-19). A substantial number of SARS-CoV-2 infection cases have been reported during the pandemic, and vaccination coverage in some regions, particularly in developing countries, remains very low. SARS-CoV-2 variants of concern (VOCs) have also emerged as some of the most pressing public health issues. In this scenario, it is crucial to know whether COVID-19 convalescent antibodies have cross-neutralizing action against VOCs to contribute to the analysis of the future progress of the pandemic.Methodology: The plasma of individuals infected with SARS-CoV-2 from June to November 2020 in Paraguay (before the first recorded infections associated with VOCs in the country) was selected. Anti-spike antibodies were determined in plasma samples (n = 626) obtained from this convalescent and unvaccinated group. Using a pseudotyped virus neutralization assay, we then investigated the neutralizing response against D614G variant and Gamma, and Delta VOCs.Results: IgG antibodies against spike were detected in 85.6% of convalescent individuals. Samples from individuals previously infected by a non-VOC showed a 6.6- and 8.1-fold reduction in neutralizing capacity to the Gamma and Delta variants, respectively, when compared to the D614G variant.Conclusions: Our findings show that antibodies generated by non-VOC infection have reduced neutralizing capabilities against Gamma and Delta variants that appeared subsequently and might have implications for immunity strategies.
PB Journal of Infection in Developing Countries
YR 2023
FD 2023-10-31
LK http://hdl.handle.net/20.500.14066/4372
UL http://hdl.handle.net/20.500.14066/4372
LA eng
NO Samudio, A., Sotelo, P. H., González-Maldonado, P., Alfonso, L., Valiente-Echeverría, F., Soto-Rifo, R., & Langjahr, P. (2023). Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population. The Journal of Infection in Developing Countries, 17(10), 1407–1412. https://doi.org/10.3855/jidc.16955
NO Corresponding author: Professor Patricia Langjahr, PhD. Facultad de Ciencias Químicas, Universidad Nacional de Asunción. San Lorenzo - Paraguay. Tel: (+595)21585562/3, Int 155. Email: plangjahr@qui.una.py
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 06-ago-2024