RT info:eu-repo/semantics/article
T1 Revisiting the dengue epidemic of 2011 in Paraguay : molecular epidemiology of dengue virus in the Asuncion metropolitan area
A1 Rojas Segovia, Alejandra María
A1 Moreira Soares, Adriana
A1 Mendoza Torres, Laura Patricia
A1 Acosta de Hetter, María Eugenia
A1 Aria, Laura Silvana
A1 Páez Acchiardi, Gloria Malvina
A1 Herebia, Lilian
A1 Vallejos, María Asunción
A1 Arévalo de Guillén, Ivalena
A1 Aquino Quintana, Víctor Hugo
AB Background. Dengue is one of the most important re-emerging viral diseases and the most common human arthropod-borne viral infection worldwide. Any of the four Dengue virus serotypes (DENV-1 to 4) can cause asymptomatic infections or clinical manifestations that range in severity from a mild, self-limited illness, to a severe disease characterized by a shock syndrome that can lead to death. Paraguay suffers periodic epidemic outbreaks of dengue since 1988 when the DENV-1 was introduced in the country. Epidemics caused by all four serotypes have been reported and the country. Although dengue is endemic in Paraguay, few studies have described the molecular epidemiology of DENV in the country, which is important to understand the local and global spread, as well as the evolution of this pathogen.Methods. This was a cross-sectional study of a convenience sample. Suspected dengue patients of any age were recruited from the Emergency Laboratory of the Central Hospital of the Institute of Social Welfare, Asuncion, Paraguay, from February to June of 2011. A DENV antigen test was used to confirm the infection. The protein E gene sequences of isolated viruses were sequenced for phylogenetic analysis.Results. Dengue was confirmed in 55.1% of the participants (n = 98/178). The most frequent clinical findings were fever, headache, and myalgia. Identity analyses of the protein E gene sequence of 56 viruses isolated showed the circulation of DENV-1 (n = 45) and DENV-2 (n = 11) in the Asuncion metropolitan area in 2011. Molecular epidemiology analyses suggest that DENV-1 was introduced into Paraguay from Argentina, while the DENV-2 from Brazil, replacing previous virus lineages.Conclusions. We have analyzed the molecular epidemiology of DENV-1 and DENV-2 isolated in Paraguay in 2011. We found strong evidence that DENV-1 was introduced into Paraguay from Argentina, while the DENV-2 from Brazil, replacing previous virus lineages. Molecular epidemiology studies are of great interest to analyze the dynamic of DENV spread, which are useful for early implementation of containment measures to reduce the risk of explosive epidemics caused by this virus.
PB Springer Nature
YR 2021
FD 2021-08-07
LK http://hdl.handle.net/20.500.14066/4379
UL http://hdl.handle.net/20.500.14066/4379
LA eng
NO Rojas, A., Moreira Soares, A., Mendoza, L.P. et al. Revisiting the dengue epidemic of 2011 in Paraguay: molecular epidemiology of dengue virus in the Asuncion metropolitan area. BMC Infect Dis 21, 769 (2021). https://doi.org/10.1186/s12879-021-06487-9
NO Correspondence: vhugo@fcfrp.usp.br
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 19-dic-2024