RT info:eu-repo/semantics/article
T1 Genital infections in high-risk human papillomavirus positive Paraguayan women aged 30–64 with and without cervical lesions
A1 Arévalos, Alanis
A1 Valenzuela, Adriana Beatriz
A1 Mongelós Dacunte, Pamela Esther
A1 Barrios, Hernán
A1 Rodríguez Riveros, María Isabel
A1 Báez, Fátima Romina
A1 Centurión Viveros, Claudia Carolina
A1 Vester, Jaime Mauricio
A1 Soilan, Ana María
A1 Ortega, Marina
A1 Meza, Lorena
A1 Páez Acchiardi, Gloria Malvina
A1 Castro, Amalia Magdalena
A1 Cristaldo, Carmen
A1 Soskin, Ana
A1 Deluca, Gerardo
A1 Baena, Armando
A1 Herrero, Rolando
A1 Almonte, Maribel Fatima
A1 Kasamatsu, Elena Satiko
A1 Mendoza Torres, Laura Patricia
A1 ESTAMPA Paraguayan Study Group
A2 Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud
AB Objective. To determine the prevalence of genital infections (GIs), including sexual transmitted STIs: Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, and opportunistic pathogens that generally do not cause STIs, non-classic STI: Ureaplasma urealyticum, Ureaplasma parvum and Mycoplasma hominis, in women with high-risk oncogenic human papillomavirus (hr-HPV) infection and their association with cervical lesions.Methods. A cross-sectional study was carried out including 231 hr-HPV positive women. Of these, 46 has histologically confirmed cervical intraepithelial neoplasia 3 (CIN3) or more (including CIN3 and cervical cancer lesions-CIN3+). GIs were detected by multiplex real time PCR. Odds ratios (OR) were estimated to explore possible associations between GIs and the presence or absence of CIN3+ lesions. Additionally, we examined associations between sociodemographic, sexual, and clinical characteristics and the presence of GIs.Results. In total, there were 174/231 cases of GIs corresponding to an overall prevalence of 75.3% (95%CI: 69.4–80.4), being non-classic STIs the most common (72.3%) compared to STIs (12.6%). The most prevalent non-classic STI and STI were U. parvum (49.8%) and C. trachomatis (7.4%), respectively. The odds of presenting GIs were 3 times higher in women under 46 years compared to older counterparts (OR: 3.32, 95%CI: 1.74–6.16), and in women with a normal Pap smear with inflammation compared to those without inflammation (OR: 3.31, 95%CI: 1.15–9.77). GIs were equally present in women with and without CIN3+ lesions.Conclusion. We observed an association of GIs with inflammation in the Pap smear, but no association with CIN3+, as some of them are very common and likely part of the normal vaginal flora, suggesting that such infections do not appear to be cofactors in cervical carcinogenesis, although larger prospective studies are needed.
PB Public Library of Science
YR 2024
FD 2024-10-29
LK http://hdl.handle.net/20.500.14066/4504
UL http://hdl.handle.net/20.500.14066/4504
LA eng
NO Arévalos, A., Valenzuela, A., Mongelós, P., Barrios, H., Rodríguez, M. I., Báez, R., Centurión, C., Vester, J., Soilán, A., Ortega, M., Meza, L., Páez, M., Castro, A., Cristaldo, C., Soskin, A., Deluca, G., Baena, A., Herrero, R., Almonte, M., … ESTAMPA Paraguayan Study Group. (2024). Genital infections in high-risk human papillomavirus positive Paraguayan women aged 30-64 with and without cervical lesions. PloS one, 19(10), Artículo e0312947. https://doi.org/10.1371/journal.pone.0312947
NO Correspondencia: Laura Patricia Mendoza Torres, lmendoza@iics.una.py
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 19-ene-2025