RT info:eu-repo/semantics/article
T1 Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking
A1 Vera de Bilbao, Ninfa
A1 Giebelhaus, Ryland T.
A1 Dias, Ryan P.
A1 Ferreira de Paredes, María Elena
A1 Martínez, Miguel
A1 Velasco Carneros, Lorea
A1 Nam, Seo Lin
A1 de la Mata, Aidee Paulina
A1 Maréchal, Jean-Didier
A1 Adou, Ahissan Innocent
A1 Yaluff Miranda, Gloria Cristina
A1 Serna, María Elva
A1 Sylvestre, Muriel
A1 Torres, Agueda Susana
A1 Schinini Vega, Alicia Petrona
A1 Galeano, Ricardo
A1 Fournet, Alain
A1 Harynuk, James J.
A1 Cebrian Torrejon, Gerardo
A2 Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud
AB This publication reports the controlled cultivation of Zanthoxylum chiloperone var. angustifolium Engl. (Rutaceae) in several growth substrates under controlled greenhouse conditions. This plant is well-known for its anti-Chagas (trypanocidal) activity, related to the presence of several β-carboline alkaloids. The metabolomic study of Z. chiloperone seedlings over two years of growth (2018–2020) was performed using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS). The canthin-6-one alkaloids, canthin-6-one and 5-methoxy-canthin-6-one, were putatively identified in Z. chiloperone extracts. Finally, in vitro and in silico studies of trypanocidal activity were performed, suggesting that canthin-6-one alkaloids could interact with the main pharmacological targets against Trypanosoma cruzi, cruzain protease, dihydroorotate dehydrogenase, lanosterol 14-alpha-demethylase, farnesyl diphosphate, and squalene synthases.
PB Multidisciplinary Digital Publishing Institute
YR 2025
FD 2025-03-18
LK http://hdl.handle.net/20.500.14066/4552
UL http://hdl.handle.net/20.500.14066/4552
LA eng
NO de Bilbao, N. V., Giebelhaus, R. T., Dias, R. P., Ferreira, M. E., Martínez, M., Velasco Carneros, L., Nam, S. L., de la Mata, A. P., Maréchal, J. D., Adou, A. I., Yaluff, G., Serna, E., Sylvestre, M., Torres, S., Schinini, A., Galeano, R., Fournet, A., Harynuk, J. J., & Cebrián Torrejón, G. (2025). Exploring the anti-Chagas activity of Zanthoxylum chiloperone’s seedlings through metabolomics and protein-ligand docking. Plants, 14(6), Artículo 954. https://doi.org/10.3390/plants14060954
NO Correspondence: nverabilbao@gmail.com (N.V.d.B.); alain.fournet@orange.fr (A.F.)
NO This article belongs to the Section Phytochemistry.
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 12-abr-2025