RT info:eu-repo/semantics/article
T1 Association of class II HLA alleles with susceptibility to develop immune-mediated diseases in Paraguayan patients
A1 Acosta Colmán de Conrads, María Isabel
A1 Cabrera Villalba, Sonia Raquel
A1 Ayala Lugo, Ana Ilda
A1 Jolly, Valerie
A1 Vázquez Báez, Marcos Aurelio
A1 Morel Ayala, Zoilo Ramón Pastor
A1 Langjahr Penayo, Patricia Elena
A1 Duarte, Margarita
A1 Zárate Romero, Ruth Noemí
A1 Acosta de Hetter, María Eugenia
A1 Avila Pedretti, María Gabriela
A1 Julià, Antonio
A1 Martínez de Filártiga Filártiga, María Teresa
A1 Marsal, Sara
A2 Laboratorio Curie S.R.L.
AB Genetic and nongenetic factors are involved in the pathogenesis of immune-mediated inflammatory diseases (IMIDs). The best-known genetic factor for susceptibility to IMIDs is the human leukocyte antigen (HLA). The aim of the present study was to evaluate the association of HLA class II genes with the risk of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SSc) in the Paraguayan population. We included 254 patients with IMIDs (101 SLE, 103 RA, and 50 SSc) and 50 healthy controls. The haplotypes of five genes corresponding to HLA class II genes and their relationship to the IMIDs studied were determined. Note that 84.6% were women, with a mean age of 43.4 ± 14 years. Among the associated HLA alleles, we found the previously identified risk factors in other populations like HLA-DRB1*03:01 and HLA-DRB1*14:02 for RA, as well as new ones not previously identified, such as DPA1*02:01 for SLE and, DB1*02:01 for RA and SSc. In the genetic association analysis, already known associations have been replicated, and unpublished associations have been identified in Paraguayan patients with IMIDs. This is the first genetic association study in Paraguayan patients with IMIDs.
PB John Wiley and Sons
SN 1744-3121
YR 2022
FD 2022-12-21
LK http://hdl.handle.net/20.500.14066/4577
UL http://hdl.handle.net/20.500.14066/4577
LA eng
NO Acosta-Colman, I., Cabrera-Villalba, S., Ayala-Lugo, A., Jolly, V., Vazquez, M., Morel, Z., Langjahr, P., Duarte, M., Zarate, R., Acosta, M. E., Avila-Pedretti, G., Julià, A., Martinez, M. T., & Marsal, S. (2022). Association of class II HLA alleles with susceptibility to develop immune-mediated diseases in Paraguayan patients. International Journal of Immunogenetics, 50(1), 12–18. https://doi.org/10.1111/iji.12609
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 03-sep-2026