RT info:eu-repo/semantics/article
T1 Association of electrocardiographic altered P wave dispersion and vascular endothelial growth factor in rheumatoid arthritis
T2 Asociación de la dispersión de la onda P alterada electrocardiográfica y el factor de crecimiento endotelial vascular en la artritis reumatoide
A1 Centurión Alcaraz, Osmar Antonio
A1 de Abreu Trigueros, Paloma
A1 Avila Pedretti, María Gabriela
A1 Cabrera Villalba, Sonia Raquel
A1 Martínez de Filártiga Filártiga, María Teresa
A1 Paats, Astrid
A1 Torales, Judith M.
A1 Chávez, Christian O.
A1 Montiel, Carmen R.
A1 García, Laura B.
A1 Scavenius, Karina E.
A1 Falcón, Rocío del Pilar
A1 Candia, José C.
A1 Meza, Alfredo J.
A1 Acosta Colmán de Conrads, María Isabel
A2 Laboratorio Curie S.R.L.
AB Objectives. Serum vascular endothelial growth factor (VEGF) levels correlate with structural alterations in Rheumatoid Arthritis (RA). Since P wave dispersion (PWD) is associated with atrial ischemic-related fibrotic changes, it was conceived that there may be a correlation between altered PWD and increased VEGF levels in RA.Methods. In this prospective observational study, we evaluated patients with RA, and compared them to control subjects. PWD was considered as the difference between the maximum and minimum duration of the P wave. An altered PWD was considered one that had dispersion≥38ms. Measurements of VEGF serum levels were performed using enzyme-ligand, immunosorbent measurement ELISA kits.Results. A total of 99 patients with RA, and 48 control subjects were evaluated. The PWD was 25.3±4.9ms in the control group vs. 57±14.9ms (p<0.0001) in the RA group. No patient in the control group had altered PWD, while 94 (95%) patients in the RA group presented it (p<0.0001). The value of VEGF in the control group was 15.2±15.1pg/ml vs 51.1±55.5pg/ml (p<0.001) in RA. The value of VEGF in RA without altered PWD was 20±12pg/ml vs 56±57pg/ml in RA with altered PWD (p<0.02). An elevated VEGF value had a specificity of 80%, and a positive predictive accuracy of 95% in predicting altered PWD in RA.Conclusions. This study establishes for the first time that RA patients who possess significantly higher serum levels of VEGF have an altered PWD. The presence of an elevated VEGF serum value has a high specificity, and high positive predictive accuracy of the existence of altered PWD in RA.
PB Sociedad Española de Reumatología
SN 1699-258X
YR 2025
FD 2025-04-17
LK http://hdl.handle.net/20.500.14066/4579
UL http://hdl.handle.net/20.500.14066/4579
LA eng
NO Centurión, O. A., de Abreu, P., Avila-Pedretti, G., Cabrera, S. R., Martínez de Filártiga, M. T., Paats, A., Torales, J. M., Chávez, C. O., Montiel, C. R., García, L. B., Scavenius, K. E., Falcón, R. P., Candia, J. C., Meza, A. J., & Acosta-Colmán, I. (2025). Association of electrocardiographic altered P wave dispersion and vascular endothelial growth factor in rheumatoid arthritis. Reumatología Clínica, 21(4), Artículo 501856.https://doi.org/10.1016/j.reuma.2025.501856
DS MINDS@UW
RD 03-sep-2026