RT info:eu-repo/semantics/article
T1 LanDis : the disease landscape explorer
A1 Caniza Vierci, Horacio José
A1 Cáceres Silva, Juan José
A1 Torres Bobadilla, Mateo Fernando
A1 Paccanaro, Alberto
A2 Universidad Católica Nuestra Señora de la Asunción
A2 Cámara Paraguaya de Exportadores y Comercializadores de Cereales y Oleaginosas
A2 Centro de Ingeniería para la InvestigaciónDesarrollo e Innovación Tecnológica
AB From a network medicine perspective, a disease is the consequence of perturbations on the interactome. These perturbations tend to appear in a specific neighbourhood on the interactome, the disease module, and modules related to phenotypically similar diseases tend to be located in close-by regions. We present LanDis, a freely available web-based interactive tool (https://paccanarolab.org/landis) that allows domain experts, medical doctors and the larger scientific community to graphically navigate the interactome distances between the modules of over 44 million pairs of heritable diseases. The map-like interface provides detailed comparisons between pairs of diseases together with supporting evidence. Every disease in LanDis is linked to relevant entries in OMIM and UniProt, providing a starting point for in-depth analysis and an opportunity for novel insight into the aetiology of diseases as well as differential diagnosis.
PB Springer Nature
SN 1018-4813
YR 2024
FD 2024-01-10
LK http://hdl.handle.net/20.500.14066/4734
UL http://hdl.handle.net/20.500.14066/4734
LA eng
NO Caniza, H., Cáceres, J. J., Torres, M., & Paccanaro, A. (2024). LanDis: the disease landscape explorer. European Journal of Human Genetics, 32, 461-465.https://doi.org/10.1038/s41431-023-01511-9
NO Corresponding author. Correspondence to Alberto Paccanaro. Email: alberto.paccanaro@rhul.ac.uk.
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 04-sep-2026