RT info:eu-repo/semantics/article
T1 Short-term repeat HPV testing for triaging HPV-positive women in cervical cancer screening
A1 Baena Zapata, Armando
A1 Picconi, María Alejandra
A1 Mendoza Torres, Laura Patricia
A1 Ferrera, Annabelle
A1 Mesher, David
A1 Lineros, Johana
A1 Brizuela, Marisol
A1 Mongelós Dacunte, Pamela Esther
A1 Cabrera, Yessy
A1 Fellner, Maria Dolores
A1 Zambrana, Osmalia
A1 García, Laura
A1 Hernández, Pilar
A1 Bobadilla Frizzola, María Liz
A1 Ramon, María
A1 Venegas, Gino
A1 Villagra Carrón, Verónica
A1 Cruz, Aurelio
A1 Rodríguez, Guillermo
A1 Terán, Carolina
A1 Calderón, Alejandro
A1 Wiesner, Carolina
A1 Herrero, Rolando
A1 Almonte, Maribel
A1 ESTAMPA Study Group
AB Background. Persistent HPV infection causes cervical cancer, but most infections are transient. Triage methods identify high-risk women needing further evaluation or treatment. We assessed short-term repeat HPV testing as an alternative triage option.Methods. In ESTAMPA, women aged 30–64 years were screened with HPV testing (HC2 or Cobas) and cytology. Screen positives were referred to colposcopy approximately two months after screening, where cervical samples were collected again for repeat HPV testing. We evaluated the performance of repeat HPV for CIN3+ among HPV-positive women and explored its combination with limited HPV genotyping (HPV16/18).Results. Among 5390 HPV-positive women (including 629 CIN3 cases and 53 cancers), 61% retested positive at ~2 months (median: 1.8, interquartile range: 1.2–2.8). Repeat HPV sensitivity for CIN3+ was 81.5% (95% CI 77.2–85.2) for HC2 and 87.7% (83.7–90.8) for Cobas. Specificity was <50% with referral rates of 57.4% (55.7–59.0) and 68.2% (66.1–70.2) for HC2 and Cobas. HPV16/18 genotyping followed by repeat HPV among non-HPV16/18-positive women did not greatly improve performance. However, HPV16/18 positivity doubled the risk of CIN3+, supporting its combination with repeat HPV when available.Conclusions. Short-term repeat HPV testing could be a practical option for triaging HPV-positive women, either alone or in combination with limited HPV genotyping.
PB Springer Nature
SN 0007-0920
YR 2025
FD 2025-10-03
LK http://hdl.handle.net/20.500.14066/4813
UL http://hdl.handle.net/20.500.14066/4813
LA eng
NO Baena, A., Picconi, M. A., Mendoza, L., Ferrera, A., Mesher, D., Lineros, J., Brizuela, M., Mongelos, P., Cabrera, Y., Fellner, M. D., Zambrana, O., García, L., Hernández, P., Bobadilla, M. L., Ramon, M., Venegas, G., Villagra, V., Cruz, A., Rodríguez, G., … ESTAMPA study group. (2025). Short-term repeat HPV testing for triaging HPV-positive women in cervical cancer screening. British Journal of Cancer, 133(12), 1844–1853. https://doi.org/10.1038/s41416-025-03193-0
NO Consejo Nacional de Ciencia y Tecnología
DS MINDS@UW
RD 03-sep-2026