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dc.contributor.authorCáceres Silva, Juan José 
dc.contributor.authorPaccanaro, Alberto 
dc.contributor.otherUniversidad Católica "Nuestra Señora de la Asunción" (PY)es
dc.contributor.otherUniversity of London (UK)es
dc.date.accessioned2022-04-21T02:23:58Z
dc.date.available2022-04-21T02:23:58Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.14066/2998
dc.description.abstractIn this paper we perform an exploratory analysis of the genotypic and genotypic relation between drugs and heritable diseases. Since drugs and diseases are a priori incomparable sets, we propose a drug-disease category mapping, to define an intended objective of drug design. We establish metrics such as the locality and functional similarity of drug targets, to quantify their specificity and possible side effects. The locality of drug targets can be used to analyse the physical mechanism of action drugs use to treat diseases. On the other hand, functional similarity of drug targets reveals functions that can be exploited for drug repursosing.es
dc.description.sponsorshipCONACYT – Consejo Nacional de Ciencia y Tecnologíaes
dc.language.isoenges
dc.subject.classification6 Producción y tecnología industriales
dc.subject.otherDRUG TARGETSes
dc.subject.otherPROTEIN-PROTEIN INTERACTION NETWORKes
dc.titleAn Exploratory Analysis on Drug Target Localityes
dc.typeresearch articlees
dc.description.fundingtextPROCIENCIAes
dc.relation.projectCONACYT14-INV-088es
dc.rights.accessRightsopen accesses
dc.subject.ocdeFARMACOLOGIAes


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  • Artículos científicos
    La colección comprende artículos científicos, revisiones y artículos de conferencia que son resultados de actividades de I+D financiadas por el Programa PROCIENCIA.

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