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dc.contributor.authorParra Aguiara, Cristina
dc.contributor.authorKadomatsu Hermosa, Maridian J.
dc.contributor.authorCebrian, Jorge
dc.contributor.authorSchaerer Serra, Christian Emilio 
dc.contributor.otherUniversidad Nacional de Asunción - Facultad Politécnicaes
dc.date.accessioned2022-04-24T14:59:57Z
dc.date.available2022-04-24T14:59:57Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.14066/3343
dc.description.abstract"The present work introduces a mathematical model, based on conservation laws and Maxwell-Stefan equations of mass transport, to analyze the electrophoretic mobility of two topological DNA families: supercoiled and knotted DNA molecules with the same total molecular mass. Comparison of experimental results and numerical simulations showed that our model is able to accurately reproduce two-dimensional (2D) agarose gel electrophoresis of supercoiled dimers and nicked knotted dimers under different conditions of electrostatic potential. The implementation of this mathematical approach could be useful to optimize conditions for the separation of different types of DNA topoisomers during electrophoresis."es
dc.description.sponsorshipCONACYT - Consejo Nacional de Ciencias y Tecnologíaes
dc.language.isoenges
dc.subject.classification1303 I+D en relación con las Ciencias médicases
dc.subject.otherMEDICINAes
dc.subject.otherGENETICAes
dc.subject.otherBIOQUIMICAes
dc.subject.otherADNes
dc.subject.otherBIOINFORMATICAes
dc.titleNumerical simulation of two-dimensional agarose gel electrophoresis of knotted and supercoiled DNA moleculeses
dc.typeresearch articlees
dc.description.fundingtextPROCIENCIAes
dc.relation.projectCONACYT14-INV-062es
dc.rights.accessRightsopen accesses


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    La colección comprende artículos científicos, revisiones y artículos de conferencia que son resultados de actividades de I+D financiadas por el Programa PROCIENCIA.

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