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CRISPR/Cas9-mediated deletion of the Wiskott-Aldrich syndrome locus causes actin cytoskeleton disorganization in murine erythroleukemia cells
dc.contributor.author | Fernández-Calleja, Vanessa | |
dc.contributor.author | Fernández Nestosa, María José | |
dc.contributor.author | Hernández, Pablo | |
dc.contributor.author | Schvartzman, Jorge Bernardo | |
dc.contributor.author | Krimer, Dora | |
dc.contributor.other | Universidad Nacional de Asunción - Facultad Politécnica | es |
dc.date.accessioned | 2022-05-02T18:48:43Z | |
dc.date.available | 2022-05-02T18:48:43Z | |
dc.date.issued | 2019-01 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14066/3848 | |
dc.description.abstract | Wiskott-Aldrich syndrome (WAS) is a recessive X-linked inmmunodeficiency caused by loss-of-function mutations in the gene encoding the WAS protein (WASp). WASp plays an important role in the polymerization of the actin cytoskeleton in hematopoietic cells through activation of the Arp2/3 complex. In a previous study, we found that actin cytoskeleton proteins, including WASp, were silenced in murine erythroleukemia cells defective in differentiation. | es |
dc.description.sponsorship | CONACYT – Consejo Nacional de Ciencia y Tecnología | es |
dc.language.iso | eng | es |
dc.subject.classification | 7 Salud | es |
dc.subject.other | WISKOTT-ALDRICH | es |
dc.subject.other | ERYTHROLEUKEMIA CELLS | es |
dc.subject.other | ACTIN CYTOSKELETON | es |
dc.subject.other | CRISPR/CAS9 | es |
dc.subject.other | BRUTON TYROSINE KINASE | es |
dc.title | CRISPR/Cas9-mediated deletion of the Wiskott-Aldrich syndrome locus causes actin cytoskeleton disorganization in murine erythroleukemia cells | es |
dc.type | research article | es |
dc.identifier.doi | http://doi.org/10.7717/peerj.6284 | es |
dc.description.fundingtext | PROCIENCIA | es |
dc.journal.title | PeerJ | es |
dc.relation.projectCONACYT | PINV15-573 | es |
dc.rights.accessRights | open access | es |
dc.rights.copyright | © 2019 Fernández-Calleja et al. | es |
dc.volume.number | 7 | es |
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