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Distribution of torsional stress between the un- replicated and replicated regions in partially replicated molecules
dc.contributor.author | Martínez, Víctor | |
dc.contributor.author | Schaerer Serra, Christian Emilio | |
dc.contributor.author | Hernández, Pablo | |
dc.contributor.author | Krimer, Dora | |
dc.contributor.author | Schvartzman, Jorge Bernardo | |
dc.contributor.author | Fernández Nestosa, María José | |
dc.contributor.other | Universidad Nacional de Asunción - Facultad Politécnica | es |
dc.date.accessioned | 2022-05-02T18:50:16Z | |
dc.date.available | 2022-05-02T18:50:16Z | |
dc.date.issued | 2020-04 | |
dc.identifier.issn | 0739-1102 (Print) 1538-0254 (Online) | es |
dc.identifier.uri | http://hdl.handle.net/20.500.14066/3851 | |
dc.description.abstract | DNA topology changes continuously as replication proceeds. Unwinding of the DNA duplex by helicases is favored by negative supercoiling but it causes the progressive accumulation of positive supercoiling ahead of the fork. This torsional stress must be removed for the fork to keep advancing. Elimination of this positive torsional stress may be accomplished by topoisomerases acting solely ahead of the fork or simultaneously in the un-replicated and replicated regions after diffusion of some positive torsional strain from the un-replicated to the replicated regions by swivelling of the replication forks. | es |
dc.description.sponsorship | CONACYT – Consejo Nacional de Ciencia y Tecnología | es |
dc.language.iso | eng | es |
dc.subject.classification | 7 Salud | es |
dc.subject.other | DNA TOPOLOGY | es |
dc.subject.other | REPLICATION | es |
dc.subject.other | SUPERCOILING | es |
dc.title | Distribution of torsional stress between the un- replicated and replicated regions in partially replicated molecules | es |
dc.type | research article | es |
dc.identifier.doi | https://doi.org/10.1080/07391102.2020.1751294 | es |
dc.description.fundingtext | PROCIENCIA | es |
dc.journal.title | Journal of Biomolecular Structure and Dynamics | es |
dc.relation.projectCONACYT | PINV15-573 | es |
dc.rights.accessRights | open access | es |
dc.rights.copyright | 2020 Informa UK Limited, trading as Taylor & Francis Group | es |
dc.subject.ocde | SISTEMAS DE INFORMACION | es |
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