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dc.contributor.authorAcosta Colmán (de Conrads), María Isabel 
dc.contributor.authorMorel, Zoilo Ramón Pastor 
dc.contributor.authorAyala Lugo, Ana Ilda 
dc.contributor.authorJolly, Valerie 
dc.contributor.authorArévalo de Guillén, Ivalena 
dc.contributor.authorLangjahr Penayo, Patricia Elena 
dc.contributor.authorVázquez, Marcos
dc.contributor.authorMartínez de Filártiga, María Teresa 
dc.contributor.authorAcosta de Hetter, María Eugenia 
dc.contributor.otherLaboratorio Curie S.R.Les
dc.date.accessioned2023-10-04T20:27:23Z
dc.date.available2023-10-04T20:27:23Z
dc.date.issued2023-07-17
dc.identifier.citationAcosta-Colman, I., Morel, Z., Ayala Lugo, A., Jolly, V., de Guillén, I., Langjahr, P., Vázquez, M., Martínez de Filártiga, M., & Acosta, M. (2023). Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients. Reumatismo, 75 (2). https://doi.org/10.4081/reumatismo.2023.1541en
dc.identifier.issn2240-2683es
dc.identifier.urihttp://hdl.handle.net/20.500.14066/4307
dc.descriptionCorresponding author: Isabel Acosta-Colman, Department of Rheumatology, Faculty of Medical Sciences, National University of Asunción, San Lorenzo, Paraguay; email: dr.acostacolman@gmail.comes
dc.description.abstractSystemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a heterogeneous clinical picture that makes the diagnosis and follow-up of these patients difficult. This study aimed to identify correlations between clinical, immunological, and genetic biomarkers and clinical manifestations in SLE. A retrospective study of data from medical records and immunological and genetic studies of SLE patients in Paraguay was carried out. A descriptive analysis was performed based on the type of variable. Human leukocyte antigen (HLA) allele frequencies (DPA1, DPB1, DQA1, DQB1, and DRB1) were calculated, and univariate logistic regression analyses were performed between each of the explanatory variables and the presence or absence of each phenotype. Odds ratios, 95% confidence intervals, and p values were recorded. Associations with p<0.05 were considered statistically significant. 104 SLE patients were included: 86% were female, with a mean age of 32.80±10.36 years. An association was identified between anti-double stranded DNA (antidsDNA) and the presence of the renal phenotype and between anti-dsDNA and the absence of the joint and hematological phenotypes. Immunoglobulin M isotype rheumatoid factor was associated with the absence of a renal phenotype. HLA-DQB1*02:02 and HLA-DRB1*07:01 were associated with the cutaneous phenotype. An association was identified between age at disease onset over 30 years and the presence of the joint phenotype. No other associations were identified. Potential clinical, immunological, and genetic biomarkers of phenotypes have been identified in SLE Paraguayan patients.es
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnologíaes
dc.language.isoenges
dc.publisherPAGEPresses
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.classification7 Saludes
dc.subject.otherBiomarkerses
dc.subject.otherParaguayanes
dc.subject.otherPhenotypeses
dc.subject.otherSystemic lupus erythematosuses
dc.titleClinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patientses
dc.typeresearch articlees
dc.identifier.doi10.4081/reumatismo.2023.1541es
dc.description.fundingtextPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrolloes
dc.issue.number2es
dc.journal.titleReumatismoes
dc.page.initial65es
dc.page.final75es
dc.relation.projectCONACYT14-INV-039es
dc.rights.accessRightsopen accesses
dc.rights.copyright© 2023 the Author(s)es
dc.volume.number75es


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