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dc.contributor.authorBorges Strauss, Adolfo 
dc.contributor.authorGraham, Matthew R.
dc.contributor.authorCândido, Denise M.
dc.contributor.authorPardal, Pedro P. O.
dc.contributor.otherCentro para el Desarrollo de la Investigación Científicaes
dc.date.accessioned2024-03-20T20:23:04Z
dc.date.available2024-03-20T20:23:04Z
dc.date.issued2021-11-29
dc.identifier.citationBorges, A., Graham, M. R., Cândido, D. M., & Pardal, P. P. O. (2021). Amazonian scorpions and scorpionism: integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world's most diverse rainfores. Journal of Venomous Animals and Toxins including Tropical Diseases, 27, e20210028. https://doi.org/10.1590/1678-9199-JVATITD-2021-0028en
dc.identifier.otherhttps://doi.org/10.1590/1678-9199-JVATITD-2021-0028es
dc.identifier.urihttp://hdl.handle.net/20.500.14066/4393
dc.descriptionCorrespondence: borges.adolfo@gmail.comen
dc.description.abstractVenom from Amazonian scorpions of the genus Tityus contains components capable of eliciting a distinct clinical, mostly neurological, syndrome. This contrasts with the mainly autonomic manifestations produced after envenomation by congeneric southern and northern South American species. Herein, we summarize Pan-Amazonian scorpionism by synthesizing available toxinological, clinical, and molecular data gathered from all affected areas in Amazonia, including Brazil, Ecuador, Colombia, Peru, Venezuela, and French Guiana. We searched multiple databases, as well as our own records, for reports of scorpion envenomations in Amazonia by confirmed Tityus spp., and compared the clinical manifestations. To help uncover clinical and venom relationships among problematic species, we explored phylogenetic relationships with a rate-calibrated analysis of mitochondrial COI data from available species. The possible existence of diversity gradients for venom toxic and immunogenic components despite the predicted strong phylogenetic association among species is underscored by discussed clinical and toxinological findings. A multicentric effort, involving all nations affected by this neglected disease, is urgently needed to offer alternatives for treating and understanding this pathology, including the preparation of neutralizing antibodies with a broad range of efficacy.es
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnologíaes
dc.format.extent20 páginases
dc.language.isoenges
dc.publisherSão Paulo State University. Center for the Study of Venoms and Venomous Animalses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.classification7. Saludes
dc.subject.otherAmazoniaes
dc.subject.otherScorpionismes
dc.subject.otherScorpion antivenomes
dc.subject.otherTityuses
dc.titleAmazonian scorpions and scorpionism : integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world’s most diverse rainforestes
dc.typeinfo:eu-repo/semantics/reviewes
dc.identifier.doi10.1590/1678-9199-JVATITD-2021-0028es
dc.description.fundingtextPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Programa de repatriación y radicación de investigadores del exteriores
dc.identifier.essn1678-9199es
dc.journal.titleJournal of Venomous Animals and Toxins including Tropical Diseaseses
dc.relation.projectCONACYTPRID18-12es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.copyright© The Author(s). 2021. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.es
dc.volume.number27es


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