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An Exploratory Analysis on Drug Target Locality
dc.contributor.author | Cáceres Silva, Juan José | |
dc.contributor.author | Paccanaro, Alberto | |
dc.contributor.other | Universidad Católica "Nuestra Señora de la Asunción" (PY) | es |
dc.contributor.other | University of London (UK) | es |
dc.date.accessioned | 2022-04-21T02:23:58Z | |
dc.date.available | 2022-04-21T02:23:58Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14066/2998 | |
dc.description.abstract | In this paper we perform an exploratory analysis of the genotypic and genotypic relation between drugs and heritable diseases. Since drugs and diseases are a priori incomparable sets, we propose a drug-disease category mapping, to define an intended objective of drug design. We establish metrics such as the locality and functional similarity of drug targets, to quantify their specificity and possible side effects. The locality of drug targets can be used to analyse the physical mechanism of action drugs use to treat diseases. On the other hand, functional similarity of drug targets reveals functions that can be exploited for drug repursosing. | es |
dc.description.sponsorship | CONACYT – Consejo Nacional de Ciencia y Tecnología | es |
dc.language.iso | eng | es |
dc.subject.classification | 6 Producción y tecnología industrial | es |
dc.subject.other | DRUG TARGETS | es |
dc.subject.other | PROTEIN-PROTEIN INTERACTION NETWORK | es |
dc.title | An Exploratory Analysis on Drug Target Locality | es |
dc.type | research article | es |
dc.description.fundingtext | PROCIENCIA | es |
dc.relation.projectCONACYT | 14-INV-088 | es |
dc.rights.accessRights | open access | es |
dc.subject.ocde | FARMACOLOGIA | es |
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