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dc.contributor.authorMesquita Ramírez, Mirta
dc.contributor.authorZárate, Mirian Noemí 
dc.contributor.authorRodríguez, Leonidas Adelaida
dc.contributor.authorAquino Quintana, Víctor Hugo 
dc.contributor.otherSalud y Nutrición - Paraguay SRLes
dc.date.accessioned2024-01-30T00:42:55Z
dc.date.available2024-01-30T00:42:55Z
dc.date.issued2023-10-05
dc.identifier.citationRamirez MM, Zarate MN, Rodriguez LA, Aquino VH (2023) Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARSCoV-2 detection in a pediatric hospital setting. PLoS ONE 18(10): e0292314. https://doi.org/10.1371/journal.pone.0292314es
dc.identifier.urihttp://hdl.handle.net/20.500.14066/4366
dc.descriptionAutor de correspondencia: vhaquino@iics.una.pyes
dc.description.abstractThe highly contagious nature of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), requires rapid diagnostic tests to prevent the virus from spreading within hospitals and communities. Reverse transcription followed by the polymerase chain reaction (RT-PCR) test is the gold standard for detecting SARS-CoV-2 infections but is time-consuming, labor-intensive, and restricted to centralized laboratories. There is a growing need to develop and implement point-of-care and rapid tests for SARS-CoV-2 detection to address these limitations. We aimed to evaluate the performance of BioFire Film Array Respiratory Panel 2.1 (BioFire FA-RP2.1) for SARS-CoV-2 detection in a pediatric hospital setting. The BioFire FA-RP2.1 test provides rapid results and can identify several viral and bacterial infections in a single test. This prospective, cross-sectional, diagnostic accuracy study enrolled participants ranging from 0 to 18 years of age, seeking medical consultation for any reason, who had been in contact with individuals confirmed to have COVID-19 or managed at the hospital for medical or surgical reasons. We employed a systematic sampling technique to ensure a representative sample. The study included 339 participants with a median age of 5 years. The BioFire FA-RP2.1 test detected SARS-CoV-2 in 18.6% of cases, while the reference RT-PCR test in 14% of cases. The BioFire FA-RP2.1 sensitivity and specificity for SARS CoV-2 detection were 98% and 94%, respectively. The positive probability coefficient (LR+) was 18. The agreement between the two tests was 0.80. In addition, the BioFire FA-RP2.1 test detected coinfection with two viruses in 7,6% of cases. The BioFire FA-RP2.1 is a reliable solution to meet pediatric healthcare needs and improve prognosis in the post-pandemic era thanks to its friendly interface and rapid testing process.es
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnologíaes
dc.language.isoenges
dc.publisherPublic Library of Sciencees
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.classification7 Saludes
dc.subject.otherCOVID-19/diagnósticoes
dc.subject.otherEstudios prospectivoses
dc.subject.otherEstudios transversaleses
dc.subject.otherHospitales pediátricoses
dc.subject.otherNiñoes
dc.subject.otherPreescolares
dc.subject.otherSARS-CoV-2/genéticaes
dc.subject.otherSensibilidad y especificidades
dc.subject.otherCOVID-19/diagnosises
dc.subject.otherProspective studieses
dc.subject.otherCross-sectional studieses
dc.subject.otherHospitals, Pediatrices
dc.subject.otherChildes
dc.subject.otherChild, Preschooles
dc.subject.otherSARS-CoV-2/geneticses
dc.subject.otherSensitivity and specificityen
dc.titlePerformance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital settinges
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1371/journal.pone.0292314es
dc.description.fundingtextPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrolloes
dc.identifier.essn1932-6203es
dc.issue.number10es
dc.journal.titlePLOS ONEes
dc.relation.projectCONACYTPINV20-287es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.copyright© 2023 Ramirez et al.es
dc.volume.number18es


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