Drug Cocktail Selection for the Treatment of Chagas Disease: a Multi-objective Approach

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URI
http://hdl.handle.net/20.500.14066/2831
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Author(s)
Torres, Mateo; Cáceres Silva, Juan JoséCONACYT Authority; Jiménez, Rubén; Yubero Rodríguez, Víctor Andrés; Vega, Maria CelesteCONACYT Authority; Rolón, Miriam SoledadCONACYT Authority; Cernuzzi, Luca CarloCONACYT Authority; Barán Cegla, BenjamínCONACYT Authority; Paccanaro, AlbertoCONACYT Authority
Date of publishing
2017
Type of publication
research article
Subject(s)
Abstract
Chagas disease is a parasitic disease, endemic in South America. As of today, there is no effective treatment in its chronic stage. We have recently identified 134 FDA approved drugs with potential antitrypanosomal activity. In this paper, we propose a novel method for selecting combinations of drugs (drug cocktails), to provide a more effective treatment against Chagas disease. We define three measures to evaluate the predicted performance of a cocktail, establishing in this way a mathematical foundation for its analysis.
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