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dc.contributor.authorTorres, Mateo
dc.contributor.authorCáceres Silva, Juan José 
dc.contributor.authorJiménez, Rubén
dc.contributor.authorYubero Rodríguez, Víctor Andrés
dc.contributor.authorVega Gómez, María Celeste 
dc.contributor.authorRolón, Miriam Soledad 
dc.contributor.authorCernuzzi, Luca Carlo 
dc.contributor.authorBarán Cegla, Benjamín 
dc.contributor.authorPaccanaro, Alberto 
dc.contributor.otherUniversidad Católica Nuestra Señora de la Asunciónes
dc.date.accessioned2022-04-06T21:49:05Z
dc.date.available2022-04-06T21:49:05Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.14066/2831
dc.description.abstractChagas disease is a parasitic disease, endemic in South America. As of today, there is no effective treatment in its chronic stage. We have recently identified 134 FDA approved drugs with potential antitrypanosomal activity. In this paper, we propose a novel method for selecting combinations of drugs (drug cocktails), to provide a more effective treatment against Chagas disease. We define three measures to evaluate the predicted performance of a cocktail, establishing in this way a mathematical foundation for its analysis. This allows us to model the drug cocktail selection as a multiobjective optimisation problem, that we show can be solved efficiently with state-of-the-art evolutionary algorithms. Our analysis retrieves 57 drug cocktails containing between 2 and 6 drugs. We discuss the improvement of the cocktail selection given by our method, and the application of this approach to the identification of cocktails against other parasitic diseases.es
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnologíaes
dc.language.isoenges
dc.subject.classification6 Producción y tecnología industriales
dc.subject.otherMulti-objective optimisationen
dc.subject.otherDrug repurposingen
dc.subject.otherChagas Diseaseen
dc.subject.otherGenetic Algorithmsen
dc.subject.otheres
dc.subject.otheres
dc.titleDrug cocktail selection for the treatment of Chagas disease : a multi-objective approaches
dc.typeresearch articlees
dc.description.fundingtextPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrolloes
dc.relation.projectCONACYT14-INV-088es
dc.rights.accessRightsopen accesses
dc.rights.copyright© 2017 IEEEes
dc.subject.ocdeFARMACOLOGIAes


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