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dc.contributor.authorRojas Segovia, Alejandra María 
dc.contributor.authorCardozo Segovia, Fátima María 
dc.contributor.authorCantero, César
dc.contributor.authorStittleburg, Victoria
dc.contributor.authorLópez, Sanny
dc.contributor.authorBernal, Cynthia
dc.contributor.authorGiménez Acosta, Francisco Eugenio
dc.contributor.authorMendoza Torres, Laura Patricia 
dc.contributor.authorPinsky, Benjamin A.
dc.contributor.authorArévalo de Guillén, Ivalena 
dc.contributor.authorPáez Acchiardi, Gloria Malvina 
dc.contributor.authorWaggoner, Jesse J.
dc.date.accessioned2024-02-27T13:26:37Z
dc.date.available2024-02-27T13:26:37Z
dc.date.issued2019-10-09
dc.identifier.citationRojas A, Cardozo F, Cantero C, Stittleburg V, López S, Bernal C, Gimenez Acosta FE, Mendoza L, Pinsky BA, Arévalo de Guillén I, Páez M, Waggoner J. 2019. Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay. PeerJ 7:e7852 http://doi.org/10.7717/peerj.7852en
dc.identifier.otherhttps://doi.org/10.7717/peerj.7852
dc.identifier.urihttp://hdl.handle.net/20.500.14066/4373
dc.descriptionCorresponding authors: Alejandra Rojas, alerojaspy@gmail.com; Jesse Waggoner, jesse.waggoner@emoryhealthcare.orgen
dc.description.abstractBackground. In 2018, Paraguay experienced a large dengue virus (DENV) outbreak. The primary objective of this study was to characterize dengue cases in the Central Department, where the majority of cases occur, and identify factors associated with DENV infection. Methods. Patients were enrolled from January-May 2018 if they presented with a suspected arboviral illness. Acute-phase specimens (≤8 days after symptom onset) were tested using rRT-PCR, a rapid diagnostic test for DENV nonstructural protein 1 (NS1) and anti-DENV IgM and IgG, and ELISA for IgG against NS1 from Zika virus (ZIKV). Results. A total of 231 patients were enrolled (95.2% adults) at two sites: emergency care and an outpatient clinical site. Patients included 119 (51.5%) dengue cases confirmed by rRT-PCR (n = 115, 96.6%) and/or the detection of NS1 and anti-DENV IgM (n = 4, 3.4%). DENV-1 was the predominant serotype (109/115, 94.8%). Epidemiologically, dengue cases and non-dengue cases were similar, though dengue cases were less likely to reside in a house/apartment or report a previous dengue case. Clinical and laboratory findings associated with dengue included red eyes, absence of sore throat, leucopenia and thrombocytopenia. At an emergency care site, 26% of dengue cases (26/100) required hospitalization. In univariate analysis, hospitalization was associated with increased viral load, anti-DENV IgG, and thrombocytopenia. Among dengue cases that tested positive for IgG against ZIKV NS1, the odds of DENV NS1 detection in the acute phase were decreased 10-fold (OR 0.1, 0.0–0.3). Conclusions. Findings from a predominantly adult population demonstrate clinical and laboratory factors associated with DENV infections and the potential severity of dengue in this group. The combination of viral load and specific IgG antibodies warrant further study as a prognostic to identify patients at risk for severe disease.es
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnologíaes
dc.format.extent20 páginases
dc.language.isoenges
dc.publisherPeerJ Inc.es
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.classification7. Saludes
dc.subject.otherAnti-NS1 antibodyes
dc.subject.otherDengue viruses
dc.subject.otherDiagnosises
dc.subject.otherEpidemiologyes
dc.subject.otherGlobal healthes
dc.subject.otherHospitalizationes
dc.subject.otherInfectious diseaseses
dc.subject.otherNS1es
dc.subject.otherRT-PCRes
dc.subject.otherViral loades
dc.titleCharacterization of dengue cases among patients with an acute illness, Central Department, Paraguayes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.7717/peerj.7852es
dc.description.fundingtextPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Financiamiento para la vinculación de científicos y tecnólogoses
dc.identifier.essn2167-8359es
dc.journal.titlePeerJes
dc.relation.projectCONACYTPVCT16-66*
dc.relation.projectCONACYTPVCT17-65*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.copyright© 2019 Rojas et al. Distributed under Creative Commons CC-BY 4.0es


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